Hand sanitiser or hand washing: which is better against coronavirus?

Viruses can be active outside the body for hours, even days. Disinfectants, liquids, wipes, gels and creams containing alcohol are all useful at getting rid of them – but they are not quite as good as normal soap.

Wash your hands

So why does soap work so well on the Sars-CoV-2, the coronavirus and indeed most viruses?

The virus is a self-assembled nanoparticle in which the weakest link is the lipid (fatty) bilayer. Soap dissolves the fat membrane and the virus falls apart like a house of cards and dies – or rather, we should say it becomes inactive as viruses aren’t really alive.

Lets just keep washing hands when possible.

When you cough, or you sneeze, tiny droplets from the airways can fly up to 10 metres. The larger ones are thought to be the main coronavirus carriers and they can go at least two metres.

These droplets end on surfaces but the viruses remain active. Human skin is an ideal surface for a virus. It is “organic” and the proteins and fatty acids in the dead cells on the surface interact with the virus.

When you touch, say, a steel surface with a virus particle on it, it will stick to your skin and hence get transferred on to your hands. If you then touch your face, especially your eyes, nostrils or mouth, you can get infected. And it turns out that most people touch their face once every two to five minutes.

Washing the virus off with water alone might work. But water is not good at competing with the strong, glue-like interactions between the skin and the virus. Water isn’t enough.

Soapy water is totally different. Soap contains fat-like substances known as amphiphiles, some of which are structurally very similar to the lipids in the virus membrane. The soap molecules “compete” with the lipids in the virus membrane. This is more or less how soap also removes normal dirt from the skin.

The soap not only loosens the “glue” between the virus and the skin but also the Velcro-like interactions that hold the proteins, lipids and RNA in the virus together.

What Did We Learn

Alcohol-based products, which pretty much includes all “disinfectant” products, contain a high-percentage alcohol solution (typically 60-80% ethanol) and kill viruses in a similar fashion.

But soap is better because you only need a fairly small amount of soapy water, which, with rubbing, covers your entire hand easily. Whereas you need to literally soak the virus in ethanol for a brief moment, and wipes or rubbing a gel on the hands does not guarantee that you soak every corner of the skin on your hands effectively enough.

So, soap is the best, but please use alcohol-based sanitiser when soap is not handy or practical.

Reference

• Pall Thordarson is a professor of chemistry at the University of New South Wales, Sydney

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